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Explore the intersection of quantum computing and Python programming in this 27-minute PyCon US talk. Discover how quantum computers are now accessible over the internet and learn about Python SDKs for quantum programming from major tech companies. Delve into the challenges of early quantum computers and the potential of combining them with differentiable programming techniques. Through real Python examples and illustrated diagrams, gain insights into evaluating and differentiating small quantum programs on actual quantum hardware. Learn how to integrate quantum programs into larger differentiable programs and optimize hybrid quantum-classical systems. Get a firsthand look at quantum programming in Python and understand when and how to leverage these cutting-edge devices in your projects.