Explore the complex relationship between systemic racism and hypertension within the African Diaspora through this comprehensive Yale Cardiovascular Medicine Grand Rounds lecture. Delve into evidence-based research and data that illuminates how systemic inequities contribute to higher rates of hypertension among African-descended populations worldwide. Learn about the historical context, current health disparities, and potential interventions to address these challenges. Examine proposed directions for healthcare policy changes, medical practice improvements, and community-based solutions aimed at reducing the impact of systemic racism on cardiovascular health outcomes. Gain valuable insights into the intersection of social determinants of health, racial disparities, and cardiovascular medicine while understanding the importance of addressing systemic barriers to achieve health equity.