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Explore recent advances in biomolecular force field development through this comprehensive lecture focusing on nonstandard amino acid and nucleic acid parameterization. Learn about the theoretical foundations and computational methods used to model complex biomolecular systems beyond standard biological building blocks. Discover how force field parameters are derived, validated, and applied to study the structural and dynamic properties of modified proteins and nucleic acids. Examine the challenges and solutions in developing accurate force fields for non-canonical amino acids and nucleotides, including their integration into existing molecular dynamics simulation frameworks. Gain insights into the latest methodological developments that enable more precise modeling of engineered biomolecules and their interactions in various biological contexts.
