Receptors and Drugs - Epinephrine, Norepinephrine, Albuterol

This lecture explains G-protein-coupled receptor structure and ligand binding, then examines catecholamines, non-catecholamine sympathomimetics, structure–activity relationships, and the receptor specificity of epinephrine, norepinephrine, isoproterenol, and albuterol.

Syllabus

00:00:00- Intro to the lecture
00:00:24- Components of G-Protein Coupled Receptors
00:03:45- Ligand Binding Domain
00:04:40- Factors affecting interaction between the Ligand and Ligand binding domain
- Concept of Agonist and Antagonist
00:11:04- Structure activity relationship
00:13:40- Catecholamines introduction
00:21:03- Catecholamines vs non-Catecholamines
00:35:56- How Non-Catecholamines act as mixed-action agonists
00:40:24- Importance of Alpha, Beta carbons and amine groups in sympathomimetics
00:56:00- Receptor specificity of Norepinephrine, Epinephrine, Isoproterenol and Salbutamol Albuterol
01:10:24- Review of this lecture