Attend this 54-minute Grand Rounds lecture by Dr. Nicolas M Van Mieghem, Professor of Interventional Cardiology at Thoraxcenter, Erasmus University Medical Center in Rotterdam, Netherlands. Explore the current status of pre-emptive transcatheter aortic valve implantation (TAVI) for patients with moderate aortic stenosis, examining the latest evidence and clinical considerations following the TAVR unload study. Learn about the evolving role of early intervention in aortic stenosis management, including patient selection criteria, timing of intervention, and outcomes data that inform contemporary practice. Gain insights into the shift toward treating moderate aortic stenosis before symptoms develop and understand the implications for clinical decision-making in interventional cardiology practice.