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This lecture explains nucleotide synthesis and how purine and pyrimidine antimetabolites act against cancer cells. It covers the mechanisms and side effects of drugs including hydroxyurea, cladribine, gemcitabine, fluorouracil, and methotrexate.
Syllabus
Intro
De novo synthesis of purines
De novo synthesis of pyrimidines
Purine antimetabolites
Pyrimidine antimetabolites
Side effects
Taught by
Speed Pharmacology