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Explore charge effects in soft matter systems through this 34-minute conference lecture examining responsive particles and shape anisotropy. Delve into how charges influence colloidal suspension stability, structure, dynamics, and self-assembly processes, moving beyond well-understood spherical hard colloids to complex systems like ionic microgels and monoclonal antibodies. Discover how thermoresponsive ionic microgels with complex radial mass and charge density profiles affect individual particle swelling behavior and potential of mean force in both dilute and concentrated systems. Learn about controlling self-assembly processes, including colloidal molecule formation and binary crystal structures, through temperature variations, ionic strength adjustments, and external field applications. Examine the intricate charge effects in anisotropic biological particles such as monoclonal antibodies, where Y-shaped structures combined with heterogeneous charge distributions require sophisticated modeling approaches to describe potential of mean force and resulting properties. Understand how these charge effects impact solution properties, colloidal stability, phase behavior, and pharmaceutical formulation requirements for high-concentration solutions, including the role of the Gibbs-Donnan effect during ultrafiltration preparation processes that create concentration-dependent pH and ionic strength changes affecting protein-protein interactions.
