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Explore cross-tissue multicellular coordination and its disruption in cancer through this 34-minute conference talk examining a comprehensive Nature paper. Discover how diverse cell types organize within tissue niches for cohesive functioning by analyzing a single-cell transcriptomic atlas from 35 human tissues that reveals substantial inter-tissue variability in cellular composition. Learn about the identification of 12 cellular modules with distinct compositions, tissue prevalences, and spatial organizations, and understand how coordinated intercellular communication operates within these modules using spatial and perturbation data. Examine the contrasting chronological dynamics of immune cellular modules in the spleen during aging and analyze multicellular changes in breast tissue associated with menopausal trajectories and fibroblast dynamics. Investigate how cancer progression simultaneously rewires multicellular ecosystems through the loss of tissue-specific healthy organization and the emergence of convergent cancerous ecosystems, providing fundamental insights into organizing principles of multicellular coordination in both health and disease states.
