Overview of Next Generation Sequencing in Oncology Diagnostics

Explore the comprehensive applications of next-generation sequencing (NGS) in clinical oncology diagnostics through this 73-minute webinar presented by Dr. Jeremy Segal, MD, PhD, Assistant Professor of Pathology and Director of Molecular and Cytogenetic Pathology at the University of Chicago. Learn about various NGS applications and different aspects of comprehensive genomic tests, including variants, copy number variations (CNVs), rearrangements, microsatellite instability (MSI), mutational signatures, and tumor mutational burden (TMB). Discover the testing landscape through brief coverage of different test types such as circulating tumor DNA (ctDNA) and minimal residual disease (MRD) testing. Understand the various use cases for NGS in clinical oncology diagnostics and recognize different approaches for detecting somatic mutations while exploring why comprehensive genomic profiling benefits patient outcomes. Examine the scope of NGS comprehensive oncology panels, the different types of biomarkers they can detect, and their clinical utility. Gain insights into the benefits of sequencing both DNA and RNA from the same patient sample and learn how relevant mutational signatures may be included in comprehensive genomic panels, how they are determined, and their actionability. The webinar offers PACE credits for registered Labroots members and provides essential knowledge for healthcare professionals working in molecular diagnostics, oncology, and personalized medicine.