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Non-Transplant Options in Pediatric Acute Liver Failure

OPENPediatrics via YouTube

Overview

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This presentation examines non-transplant management options for pediatric acute liver failure and commonly associated toxicities. It covers evolving treatment pathways, coagulation, ammonia clearance, neurocritical monitoring, and intracranial pressure management.

Syllabus

• Deep A, Nagakawa S, Tissieres P. Non-transplant options in paediatric acute liver failure-what is new?. Intensive Care Med. 2022;481:114-117.
• Habib M, Roberts LN, Patel RK, Wendon J, Bernal W, Arya R. Evidence of rebalanced coagulation in acute liver injury and acute liver failure as measured by thrombin generation. Liver Int. 2014;345:672-678.
• Slack AJ, Auzinger G, Willars C, et al. Ammonia clearance with haemofiltration in adults with liver disease. Liver Int. 2014;341:42-48.
• Hunt A, Tasker RC, Deep A. Neurocritical care monitoring of encephalopathic children with acute liver failure: A systematic review. Pediatr Transplant. 2019;237:e13556.
• Kochanek PM, Adelson PD, Rosario BL, et al. Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury. JAMA Netw Open. 2022;53:e220891.

Taught by

OPENPediatrics

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