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Explore a conference presentation that introduces a novel approach for enabling efficient cross-instruction set architecture (ISA) checkpoint and restoration using ahead-of-time (AOT) compilation of WebAssembly programs. Learn how researchers from Kyoto University address the critical challenge of live migration in heterogeneous computing environments where applications must move seamlessly between ARM, x86, and other processor architectures. Discover how their innovative solution leverages on-stack replacement (OSR) techniques, traditionally used in JIT compilers, to transform between ISA-dependent machine states and ISA-independent WebAssembly states. Understand the implementation details of Wanco, their WebAssembly AOT compiler that supports Linux on ARM-v8 and x86-64 architectures, and examine how it enables checkpointing without disabling modern CPU security features like Control-flow Integrity (CFI). Analyze the performance evaluation results showing significant improvements over CRIU, the standard Linux process migration tool, with checkpoint time reductions of 1.0–5.1 times and snapshot size reductions of 1.1–25 times, while maintaining an average execution-time overhead of only 36%. Gain insights into the technical challenges of cross-ISA migration and the innovative solutions that make efficient heterogeneous computing environments possible.