Mapping CAR T Cell Therapy - Strategies to Maximize Expansion, Persistence, Trafficking and Efficacy

Explore advanced strategies to overcome key limitations in CAR T-cell therapy through this 27-minute webinar presented by Dr. Joseph A. Fraietta from the University of Pennsylvania. Examine the mechanisms that constrain CAR T-cell expansion, persistence, and trafficking in current clinical applications, particularly in hematologic malignancies and solid tumors. Learn about innovative engineering approaches including antigen-bridging vaccination concepts, methods to preserve stem-like and resident-memory T-cell states, and locoregional delivery techniques to improve tumor infiltration. Discover how microenvironment-aware designs can enhance CAR T-cell activity within solid tumors and review emerging preclinical and clinical data supporting these interventions. Analyze practical considerations for translating these biological insights into safer, more effective clinical protocols while minimizing toxicity. Gain a comprehensive framework for selecting and combining therapeutic interventions that maximize CAR T-cell potency and durability across different cancer indications, with specific focus on addressing antigen heterogeneity and optimizing long-term antitumor responses.