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Explore the intricate relationship between lymphatic system transport and vaccine design in this 58-minute webinar presented by James Moore from Imperial College London. Delve into the critical role of the prenodal lymphatic system in transporting vaccine information to lymph nodes, where adaptive immunity is facilitated. Examine the challenges of in vivo observations and learn about innovative experiments and numerical simulations investigating fluid transport in immune processes. Discover porous media mathematical models coupled with viscous flow models to simulate vaccination effects, and explore microfluidic chamber experiments visualizing cell migration. Gain insights into the impact of vaccination on rat mesenteric collecting lymphatic pumping dynamics and fluid shifts within lymph nodes. Understand the transport mechanisms of small antigens through collagen-bundle conduit structures and uncover potential strategies for modulating vaccine effectiveness through improved understanding of lymphatic transport processes.
