Explore the intersection of Large Language Models and Human-Computer Interaction in this comprehensive 37-minute tutorial that examines how HCI principles guide the design of intuitive interfaces for AI systems. Discover how LLMs process and generate human-like responses while learning about their applications in personalization and accessibility features. Investigate multimodal interactions that seamlessly integrate text, images, and voice inputs to create more natural user experiences. Analyze the significant impact of LLMs on user behavior, persuasion techniques, and engagement strategies across various digital platforms. Examine real-world case studies demonstrating LLM implementation in healthcare systems, educational platforms, and content creation tools. Address the complex challenges involved in predicting and influencing user behavior when designing LLM-powered interfaces. Conclude by exploring future research directions that will shape the integration of Large Language Models with Human-Computer Interaction methodologies.