The World is Not Flat - Leveraging 3D Whole-Brain Imaging of Pathological α-Synuclein Spreading in a Mouse Model of Early-Stage Parkinson's Disease

Attend a keynote panel webinar exploring cutting-edge 3D whole-brain imaging techniques to study pathological α-synuclein spreading in early-stage Parkinson's disease mouse models. Learn from Dr. Henrik Björk Hansen and Dr. Yasir Gallero-Salas as they present their ongoing research using light sheet fluorescence microscopy (LSFM) to provide detailed spatiotemporal insights into misfolded α-synuclein transmission. Discover how C57BL/6 male mice received unilateral intrastriatal injections of mouse α-synuclein pre-formed fibrils and were analyzed at 1-, 4-, 8-, and 12-week intervals post-injection. Explore the immunolabeling process for α-synuclein phosphorylated at serine-129, brain clearing techniques, and LSFM scanning methods. Understand how deep-learning computational analysis enables mapping of whole-brain pathological α-synuclein architecture at cellular resolution, revealing distinct stages of aggregate spreading and toxicity in neural circuit-dependent patterns. Gain insights into preclinical synucleinopathy models and their potential for identifying early pathological events that could be targeted to delay or prevent Parkinson's disease progression. Participate in a live Q&A session and earn PACE credits through Labroots' accredited program.