DNA Origamis - Their Folding Process and Their Interactions with Lipid Membranes

Explore the fundamental aspects of DNA nanotechnology through this 27-minute conference lecture examining DNA origami folding processes and membrane interactions. Delve into the self-assembly properties of nucleic acids used to design molecular devices, including motors and logic circuits, with particular focus on DNA origamis formed through annealing processes where long single-stranded DNA interacts with short DNA sequences. Investigate two critical open questions in the field: whether the folding process yields unique results and under what conditions annealing leads to unwanted structures. Discover how DNA origamis can be modified with hydrophobic moieties to interact with lipid bilayers, potentially forming well-defined water channels, and learn how this interaction process can be accelerated using weak external electric fields.