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Explore the evolution and key elements of ORB-SLAM, the de-facto standard for real-time discrete features Visual SLAM, in this comprehensive 59-minute lecture. Delve into the system's development from its initial 2015 publication, processing monocular video streams, to its latest version, ORB-SLAM3, which incorporates inertial information and fish-eye cameras. Discover how the system expanded to handle stereo and RGB-D video streams, multiple maps, and multiple sessions. Gain insights into Visual SLAM applications in medical endoscopy, with a focus on systems built upon ORB-SLAM fundamentals. Learn about the technology's versatility in indoor, outdoor, and intracorporeal scenes, making this lecture essential for those interested in cutting-edge visual simultaneous localization and mapping techniques.