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This IEEE conference talk explores the effectiveness of virtual reality in reducing human-computer interaction fatigue through a comprehensive multimodal assessment. Compare VR with flat video experiences by examining electroencephalogram data, functional near-infrared spectroscopy, eye movement tracking, and subjective scale measurements. Learn how fatigue increases brain activation in the Theta band of the prefrontal cortex, reduces effective connectivity between Alpha and Theta bands, decreases pupil diameter, increases blink frequency, and affects subjective experiences. Discover the differences in recovery patterns between VR and flat video groups when viewing natural scenes, with VR showing higher prefrontal cortex activation in Alpha and Theta bands while flat video demonstrates stronger Alpha band connectivity.