Individualized Hemodynamic Support for Pediatric Patients with Septic Shock

This course presents a global framework for individualized hemodynamic support in children with septic shock. It covers clinical application of flow, pressure, and filling concepts and reviews evidence on fluid use in pediatric and adult patients.

Syllabus

• Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med. 2018;63:223-230. doi:10.1016/S2213-26001830063-8
• Maitland K, Kiguli S, Opoka RO, et al. Mortality after fluid bolus in African children with severe infection. N Engl J Med. 2011;36426:2483-2495. doi:10.1056/NEJMoa1101549
• Gu W, Deng X, Lee M, et al. Rapid pathogen detection by metagenomic next-generation sequencing of infected body fluids. Nat Med. 2021;271:115-124. doi:10.1038/s41591-020-1105-z
• Meyhoff TS, Hjortrup PB, Wetterslev J, et al. Restriction of Intravenous Fluid in ICU Patients with Septic Shock. N Engl J Med. 2022;38626:2459-2470. doi:10.1056/NEJMoa2202707
• National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network, Shapiro NI, Douglas IS, et al. Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension. N Engl J Med. 2023;3886:499-510. doi:10.1056/NEJMoa2212663