Implementation of an Automated Diagnostic WES and WGS Workflow for Multiple Sample Types Using Covaris

Watch a 50-minute webinar exploring the implementation of automated whole exome sequencing (WES) and whole genome sequencing (WGS) workflows at Radboud University Medical Center's Genome Diagnostics laboratory. Learn how the lab transformed its manual processes to meet increasing diagnostic demands while maintaining rapid 15-day turnaround times. Discover the integration of Covaris mechanical shearing technology with Hamilton Microlab® STAR Liquid Handling platform to create a standardized, robust workflow capable of processing diverse sample types including blood, saliva, amniotic fluid, chorionic villus, cell lines and FFPE tissue. Gain insights into the evolution of genetic and genomic technology, the development of automated sequencing workflows, and the crucial differences between enzymatic and mechanical DNA shearing in a diagnostic setting. The presentation features Tom Hofste, head of the core facility, sharing his 20+ years of genomics experience, and Dr. Madan Ambavaram, Senior NGS Applications Scientist at Covaris, offering expert perspectives on integrating Adaptive Focused Acoustics technology into NGS library preparation workflows.