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Explore the intersection of mechanical engineering and brain cancer research through this 23-minute webinar presented by Dr. Meenal Datta from the University of Notre Dame. Discover how engineering-based approaches can advance understanding of "immunomechanics" - the generation of physical forces by immune cells - and "mechano-immunology" - the impact of physical forces on immune cell function - specifically in glioblastoma, a rare but universally fatal brain cancer. Learn about the heterogeneous and abnormal tumor microenvironment of glioblastoma, which comprises up to 50% immune cells including tumor-associated macrophages that are reciprocally regulated with mechanics in the tumor microenvironment and can drive cancer progression and treatment resistance. Examine a novel in vitro model designed to study these complex interactions and uncover targetable mechanisms to improve therapeutic response in glioblastoma and other cancers. Gain insights into how perspectives, tools, and methodologies from non-traditional fields like mechanical engineering can benefit brain cancer research by understanding and overcoming the biological, chemical, electrical, and mechanical abnormalities found in solid tumors to discover new therapeutic approaches. The webinar offers PACE credits for registered Labroots members through April 30, 2026.
