Identification of Tumor-Reactive T Cell Receptors Through Functional Single Cell Interaction Analysis for Personalized T Cell Therapy

Explore a 23-minute webinar presented by Dr. Stefan Eichmüller, head of the Research Group GMP & T Cell Therapy at the German Cancer Research Center. Delve into the identification of tumor-reactive T cell receptors through functional single cell interaction analyses for personalized T cell therapy. Learn about the promising results of adoptive transfer of chimeric antigen receptor (CAR) T cells and tumor-infiltrating lymphocytes in hematological malignancies, as well as the challenges faced in multiple myeloma treatment. Discover how T cells expressing engineered T cell receptors (TCR-T cells) offer a potential therapeutic alternative by targeting intracellular antigens. Gain insights into the project's methodology, including the use of nanofluidics and opto-electropositioning for analyzing T cell/target cell interactions, single-cell RNA sequencing, and the identification of myeloma-reactive T cells. Understand the process of validating myeloma-reactivity in transgenic T cells and the identification of T cell responses against shared and private cancer antigens. Explore the potential of this approach in facilitating patient-individualized T cell therapy for multiple myeloma patients.