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Learn to deploy AWS IAM Roles Anywhere on platforms without key management services using Let's Encrypt in this 20-minute conference talk. Discover how to overcome the common adoption barrier of lacking existing PKI solutions or the resources to run a Private CA by integrating Route 53 with ACME-enabled PKI systems like Let's Encrypt for secure device enrollment with autonomous short-lived certificate issuance. Explore the technical implementation through configuring IAM Roles Anywhere with targeted CA certificates, setting up Certificate Attribute Mappings for client authentication, and creating corresponding Trust Policies on Roles. Master extending the AWS SDK via credential helpers to transparently return temporary session credentials to calling processes. Build detection mechanisms for private key abuse using CloudTrail logs to identify potential security breaches. Compare this approach with hardware-backed private key storage solutions using Yubikey with ACME-enabled PKI systems for enhanced security scenarios.