Human-on-a-Chip for Translational PK/PD and Disease Modeling - Cardiac Ischemia, Patient-Specific Model for CMT2S, and Digital Twin Applications

Explore advanced microphysiological systems through this 36-minute webinar presented by Dr. Christopher Long, Director of Engineering and Automation at Hesperos, Inc. Learn how Human-on-a-Chip technology addresses the limitations of animal models in predicting human therapeutic outcomes by reproducing key aspects of human physiology for clinically relevant drug discovery and disease modeling insights. Discover three groundbreaking applications: a cardiac ischemia model that controls hypoxia and reperfusion within multi-organ contexts while measuring contractile force, electrophysiology, and injury biomarkers; a patient-specific neuromuscular junction model for Charcot-Marie-Tooth type 2S using iPSC-derived cells that successfully supported FDA Orphan Drug Designation; and the first published Digital Twin informed by organ-on-a-chip systems that integrates longitudinal biological data with in silico models for improved clinical translatability. Understand how quantitative pharmacokinetic-pharmacodynamic modeling combines with these platforms to reduce animal study reliance, de-risk therapeutic development, and accelerate the translation from preclinical insights to clinical decisions, particularly for rare diseases where traditional models are limited or non-existent.