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Explore the decades of groundbreaking scientific achievements made possible through UK-US space collaboration in this comprehensive symposium. Discover how UK leadership on critical instruments like MIRI for the James Webb Space Telescope, Solar Orbiter, Cassini-Huygens, and the newly launched IMAP mission has combined with NASA's mission platforms to deliver iconic breakthroughs in astrophysics, heliophysics, and planetary science. Learn from leading scientists, engineers, industry innovators, and government representatives from both nations as they celebrate shared milestones and discuss the future of transatlantic space partnerships. Gain insights through keynote presentations, panel discussions featuring experts in UK-US science collaboration, lightning round talks providing quick-fire updates on current projects, and comprehensive coverage of how UK ingenuity in instrumentation and design continues to pair with NASA's operational excellence. Understand the strategic importance of these partnerships through perspectives from co-hosting organizations including Greater Together LA, the Keck Institute for Space Studies at Caltech, the British Consulate General in LA, the UK Space Agency, and NASA's Jet Propulsion Laboratory, all working together to inspire new missions that will build on this remarkable legacy of discovery.