Graft-Versus-Host Disease

This course provides an advanced clinical review of graft-versus-host disease after hematopoietic stem cell transplantation. It covers pathophysiology, risk factors, acute and chronic manifestations, grading, prevention, treatment, and prognosis.

Syllabus

Intro
Hematopoietic Stem Cell Transplant
Sources of Stem Cells
Graft-Versus-Host Disease (GVHD)
Pathophysiology of Acute GVHD
Pathophysiology of Chronic GVHD
Risk Factors for GVHD
HLA Region of Chromosome 6
HLA Matching and GVHD Risk
Risk Factors: Stem Cell Source
Acute vs. Chronic GVHD
National Institute of Health GVHD Criteria
Features of Acute & Chronic GVHD
Chronic GVHD Diagnostic Features: Skin Lichen Planus
Chronic GVHD Diagnostic Features: Mouth
Chronic GVHD Diagnostic Features: Lungs
Chronic GVHD: Hair Manifestations
Chronic GVHD: Oral Manifestations
Ocular GVHD
GVHD: Genitourinary Manifestations
Chronic GVHD: Pulmonary Manifestations
Chronic GVHD: Hepatic Manifestations
Acute GVHD Grading
Acute GVHD: Cutaneous Staging
Acute GVHD: Gastrointestinal Staging
Acute GVHD: Hepatic Staging
Infectious Prophylaxis in GVHD
GVHD Prevention
GVHD Treatment: Steroids
Treatment of Steroid Refractory GVHD
Monoclonal Antibodies
SECONDARY THERAPIES
Acute GVHD Prognosis
Chronic GVHD Prognosis