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Explore cardiac cell state transitions and regenerative mechanisms in this 35-minute webinar presented by Dr. Mick Lee from the Cardiovascular Research Institute. Learn how genetically encoded reporter systems in human embryonic stem cells (hESCs) can be used to investigate cardiomyocyte differentiation and dedifferentiation processes. Discover the regulatory mechanisms controlling cardiac cell fate transitions, with particular focus on cardiomyocyte dedifferentiation as a critical step preceding cell cycle re-entry for cardiac regeneration. Examine the application of functional genomics approaches to study cardiac development and disease gene signatures that modulate cardiovascular cell states. Gain insights into multi-cellular 3D cardiac systems for modeling heart disease and cellular crosstalk, and understand how these advanced techniques can advance cardiac regenerative strategies for treating heart failure and cardiac injury.
