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This lecture explores the mechanisms behind fatigue, muscle wasting, and fat accumulation in Long COVID and post-vaccine syndrome (PVS) patients. Discover why many patients experience these symptoms alongside weakness, brain fog, and cognitive decline as their most common complaints. Learn about the underlying physiological processes causing these issues and explore potential management approaches to address them. The presentation draws on research showing reduced muscle strength in Long COVID patients is mediated by limb muscle mass changes. Gain valuable insights into this peculiar aspect of Long COVID that affects many patients' quality of life and understand possible solutions to these challenging symptoms.