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Explore an innovative webinar presented by Professor Lydia L. Sohn from UC Berkeley that introduces Node-Pore Sensing (NPS), a revolutionary label-free and camera-free method for screening cells. Learn how this all-electronic approach overcomes traditional flow cytometry challenges including coincidence events, irreversible antibody binding, and high shear forces that can damage cells. Discover how NPS uses a four-terminal measurement system to analyze modulated current pulses as cells transit through microfluidic channels segmented by inserted nodes, enabling the encoding of spatial and temporal information to distinguish individual cells even in coincidence events. Understand the technical principles behind this microfluidics-based platform that can simultaneously assess both immunophenotypic and mechanophenotypic cellular profiles while maintaining low shear forces to preserve cell integrity. Examine diverse applications ranging from measuring HIV viral particles in serum samples to immunophenotyping acute myeloid leukemic blasts and mechanophenotyping primary human mammary epithelial cells. Gain insights into how this technology, recognized as one of five "Revolutionary Platform Technologies for Advancing Life Sciences Research" by major foundations, is advancing biomedical research and clinical diagnostics across immunology, cancer research, and regenerative medicine fields.
