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Explore the fascinating world of canine evolution and genetics in this 54-minute Presidential Lecture that delves into how humans have shaped dog breeds through selective breeding and what genomic research reveals about our four-legged companions. Discover the evolutionary journey from wild ancestors to modern breeds, examining the genetic factors that contribute to the remarkable diversity in appearance, behavior, and health predispositions observed across different dog breeds. Learn about cutting-edge genomic studies that illuminate breed-specific disease susceptibilities and the molecular mechanisms underlying the striking phenotypic differences between breeds. Gain insights into the intersection of evolution, genomics, and genetics as researchers work to unravel the complex relationship between human intervention and canine development, providing a comprehensive understanding of how selective breeding has created the incredible variety of dogs we see today.