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Learn how spatial analysis techniques can reveal critical insights about cancer biology through examination of both human and mouse tumor samples in this medical grand rounds presentation. Explore cutting-edge methodologies for analyzing the spatial organization of cancer cells, their microenvironment, and the complex interactions that drive tumor progression and metastasis. Discover how advanced imaging technologies and computational approaches are being used to map cellular neighborhoods within tumors, identify therapeutic targets, and understand resistance mechanisms. Examine case studies demonstrating how spatial transcriptomics and proteomics can uncover previously hidden patterns in cancer development, including the role of immune cell infiltration, stromal interactions, and metabolic gradients within the tumor ecosystem. Gain insights into translational applications of spatial analysis for improving cancer diagnosis, prognosis, and treatment selection, while understanding the comparative advantages of studying both human clinical samples and mouse model systems to advance our understanding of cancer biology.
