Explore how rare stochastic events in cell biology and biophysics can be analyzed through extreme statistics in this conference talk from the Workshop on "Extremal Statistics in Biology." Learn about asymptotic computations of the Fokker-Planck equation and discover computational methods for studying molecular and cellular processes. Examine key examples of extreme statistical phenomena in biological systems, with particular focus on synaptic transmission where modeling and simulations reveal molecular organizations that have been validated through super-resolution microscopy. Gain insights into how mathematical frameworks can uncover fundamental biological mechanisms through the lens of rare events and extreme value theory.