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Explore cutting-edge developments in precision medicine through this invited lecture at the UCLA Comprehensive Cancer Center's CMINT series, focusing on computational approaches to nuclear oncology and radiopharmaceutical therapies. Delve into the evolution of anthropomorphic digital phantoms and their role in virtual clinical trials, before understanding the fundamental concepts of computational nuclear oncology. Learn about digital twin technology and its specific applications in theranostic treatments, including detailed explanations of Physiologically-based Pharmacokinetic (PBPK) models and their implementation in radiopharmaceutical therapies. Examine the challenges and potential solutions in developing theranostic digital twins, while exploring the integration of artificial intelligence in this field and future prospects for precision medicine. The presentation provides a comprehensive overview of how computational modeling and digital twin technology are revolutionizing personalized cancer treatment approaches.
