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Dive into a comprehensive 85-minute lecture on Chronic Leukemia delivered by Professor Zach Murphy, offering a high-yield breakdown of both Chronic Myeloid Leukemia (CML) and Chronic Lymphocytic Leukemia (CLL). Explore the detailed pathophysiology, including the BCR-ABL fusion gene and Philadelphia chromosome in CML, as well as the immunophenotypic markers in CLL. Learn about hallmark laboratory findings, peripheral blood smear features, and essential diagnostic tests like flow cytometry and FISH analysis. Understand the clinical manifestations and complications of these hematologic malignancies, including anemia, splenomegaly, infections, and Richter transformation. Master the treatment strategies, from tyrosine kinase inhibitors for CML to BTK inhibitors and venetoclax for CLL. Perfect for medical students preparing for USMLE, COMLEX, and PANCE exams, this structured approach includes integrated tables, clinical pearls, and board-style insights to enhance understanding of these complex hematologic disorders.
