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Explore the intricate relationship between chromatin structure and poly-ADP ribosylation (PARylation) as regulatory mechanisms in both physiological and premature aging conditions in this 28-minute webinar presented by Dr. Jong-Hyuk Lee from Mercer University School of Medicine. Discover how aging is accompanied by widespread epigenetic reprogramming, including the loss of heterochromatin and altered chromatin-associated processes that compromise transcriptional precision and genome stability. Learn about research using Cockayne Syndrome (CS) as a model of accelerated aging, demonstrating that CSB-deficient cells exhibit chromatin decompaction, increased PARylation near transcription start sites, and mitochondrial dysfunction. Understand how restoring the heterochromatin mark alleviates PAR pathology and improves mitochondrial homeostasis. Examine the novel role of mitochondrial PARP and mitochondrial nucleoid PARylation in regulating mtDNA transcription, revealing a cross-compartmental NAD⁺-dependent epigenetic signaling axis. Gain insights into how chromatin dynamics and PARylation shape aging phenotypes and discover potential avenues for therapeutic intervention in aging-related diseases. The presentation is delivered by Dr. Lee, whose research centers on the epigenetic mechanisms of aging and age-related diseases, with particular expertise in chromatin dynamics and DNA repair pathways in premature aging syndromes.
