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Explore the innovative use of genetically engineered Salmonella bacteria as a targeted cancer therapy delivery system in this 29-minute conference talk. Learn how researchers are addressing two major challenges in solid cancer treatment: systemic drug toxicity and poor drug penetration into tumor tissue. Discover the development of intracellular delivery systems that can selectively transport therapeutic proteins directly to malignant cells using modified bacterial vectors. Examine the benefits and challenges of this groundbreaking approach through discussion of recent research published in Molecular Therapy, which demonstrates how engineered Salmonella strains can serve as living vehicles for cancer therapeutics. Understand the mechanisms behind bacterial-mediated drug delivery, the genetic modifications required to make Salmonella safe and effective for therapeutic use, and the potential for this technology to revolutionize cancer treatment by improving drug specificity while reducing harmful side effects.
Syllabus
Bugging Cancer: Engineering Salmonella for Cancer Therapy
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