Bridging Scales with Brain Simulation - From Molecules to Disease Mechanisms

Explore how computational brain simulation connects molecular-level processes to disease mechanisms in this 20-minute conference talk by Leon Stefanovski from the Berlin Institute of Health at Charité. Discover the methodological approaches used to bridge different scales of brain function, from the microscopic molecular interactions to the macroscopic manifestations of neurological diseases. Learn about the computational frameworks and modeling techniques that enable researchers to understand how molecular changes cascade through neural networks to produce observable disease phenotypes. Gain insights into how multi-scale brain simulation is advancing our understanding of neurological disorders and potentially informing therapeutic interventions by revealing the mechanistic links between molecular dysfunction and clinical symptoms.