Explore the emerging paradigm of autonomous cybersecurity systems in this conference talk that examines how AI is transforming both offensive and defensive security operations. Discover how nation-state actors and cybercriminals are weaponizing artificial intelligence while learning about defensive AI agents that create self-improving security systems. Examine recent Google Threat Intelligence findings that reveal current AI-powered attack strategies and understand how constraints of cost, latency, and efficacy are shaping the machine-versus-machine security landscape. Learn about autonomous agents and domain-specific languages that enable continuous feedback loops to rapidly strengthen defensive capabilities, and gain insights into how organizations can prepare for this new era of AI-driven cybersecurity warfare.