Explore the intricate relationships between matter, energy, and information in this thought-provoking Santa Fe Institute podcast episode featuring Artemy Kolchinsky. Delve into the concept of semantic information and its role in understanding the physics of meaning. Examine how living systems maintain order by harnessing energy and information flows, and investigate the differences between exchanging heat and exchanging meaningful signals. Discover the interplay between goals, meaning, and a system's constraints in the context of emergent order. Join host Michael Garfield and SFI Program Postdoctoral Fellow Artemy Kolchinsky as they navigate through the intersections of cybernetics, cognitive science, statistical physics, and astrobiology to unravel fundamental questions about information processing in biological, neural, and physical systems.