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Explore the complexities of aging brain research in this comprehensive lecture that examines both the challenges and opportunities in understanding cognitive decline and dementia. Delve into the mechanisms underlying healthy and diseased aging processes while learning about current approaches to assess cognitive decline status. Discover the importance of collecting multimodal data including MRI, OCT, and gait analysis to build a complete picture of brain aging. Understand how proteomics and genomics data, when combined with digital biomarkers, create opportunities for developing sophisticated analytical tools and composite biomarkers for early disease detection. Learn about the potential for predictive tools to enable targeted intervention mechanisms that could halt or delay disease progression. The presentation covers current understanding of dementia, highlights assessment challenges in cognitive decline research, and discusses the integration of multiple data modalities to advance aging brain research. Gain insights into how interdisciplinary approaches combining neuroscience, engineering, and data analysis are revolutionizing our ability to detect and potentially intervene in age-related cognitive decline before symptoms become severe.
