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Learn essential techniques for developing oligonucleotide therapeutics through proper phosphoramidite synthesis, selection, and evaluation methods in this 35-minute webinar. Explore how oligonucleotide therapeutics have emerged as a promising novel class of drugs for treating a wide range of diseases, with focus on the critical role of chemical building blocks called phosphoramidites in generating high-quality oligonucleotides. Discover analytical techniques including LCMS and NMR for product testing and impurity identification, gain insights into impurity formation and control in the amidite supply chain and chemical synthesis processes, and understand best practices for phosphoramidite evaluation in oligonucleotide drug development. The session draws on nearly two decades of expertise in the phosphoramidite and nucleotide space, covering analytical development approaches and quality control methodologies essential for small molecule API manufacturing in the oligonucleotide therapeutics field.
