Acute Phase Reactants - C Reactive Protein and ESR

This 57-minute medical lecture explores the comprehensive details of acute phase reactants with special focus on C-Reactive Protein (CRP) and Erythrocyte Sedimentation Rate (ESR). Learn the definition, initiators, and cellular mechanisms involved in acute phase reactions. Discover how cytokines trigger these responses and understand the liver's crucial role in producing acute phase proteins. Differentiate between positive and negative acute phase reactants, and explore non-protein reactants. Gain in-depth knowledge about C-Reactive Protein's functions, opsonization processes, and the clinical significance of fibrinogen. Compare CRP and ESR in disease monitoring, understand their relationship to chronic inflammatory states, and examine iron's role in pathogenicity. Presented by Dr. Najeeb Lectures, this educational content is part of a premium medical education library trusted by over 2 million students worldwide.

Syllabus

00:00:00 Introduction.
00:00:50 Definition of acute phase Reactants.
00:02:08 Initiators for acute phase reactants.
00:03:23 Cells Involved in production of acute
00:04:50 Cytokines involved in production of
00:07:53 Role of Liver in production of acute
00:08:49 Positive and Negative acute phase Reactants.
00:12:15 Acute Phase Reactants other than proteins.
00:15:50 Initiators/Stimuli for production of acute
00:18:15 Positive Acute Phase Reactants.
00:18:55 C- Reactive Proteins as acute phase protein.
00:23:38 Opsonins and Opsonization.
00:25:20 Functions of CRP.
00:29:30 Fibrinogen as acute phase protein.
00:30:40 Relation of Fibrinogen to EST
00:32:43 CRP vs ESR in disease monitiring
00:34:15 APRs and chronic inflammatory states.
00:35:45 Role of Iron in Pathogenicity