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Explore how virtual prototyping accelerates early-stage design exploration in multi-vendor chiplet ecosystems through this 19-minute conference talk by Raghu Shankar, a research entrepreneur specializing in chiplet architectures. Learn about developing robust ecosystems of architecturally compatible designs during planning and prototyping phases to enable agile, high-confidence design space exploration that fosters thriving market economies. Discover the importance of collaboration among chip, chiplet, EDA, and IP vendors in open ecosystems during early development stages, allowing vendors to innovate and differentiate in specialized domains while driving toward profitability and architectural compatibility. Understand a proposed framework that complements chiplet profiling to speed up early-stage decision-making with minimal risk, facilitating identification of architecturally compatible choices, automation and scaling of assessments, and business and technical value estimates. Gain insights into how this approach drives market growth, accelerates time-to-revenue, ensures better product-market fit, and reduces non-recurring engineering costs for diverse multi-vendor designs in large system-in-packages that effectively meet diverse market needs.