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Watch a 31-minute scientific webinar exploring the physiologic role of α-synuclein in synaptic vesicle recycling, presented by Dr. Kayal Madhivanan. Delve into groundbreaking research examining how phosphorylation of α-synuclein at Ser-129, traditionally viewed as a pathologic hallmark of synucleinopathies, plays a crucial physiologic role in synaptic function. Learn about experimental findings using pHluorin assays that demonstrate how α-synuclein acts as a physiologic attenuator of neurotransmitter release through its binding to VAMP2. Discover surprising insights about phospho-incompetent and phospho-mimic α-synuclein mutants, and understand how AlphaFold2-based modeling reveals the mechanism by which Ser-129 phosphorylation enables VAMP2 binding through conformational changes. Gain valuable perspective on the implications of these findings for therapeutic approaches targeting α-synuclein phosphorylation in Parkinson's disease and related disorders.
