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Explore a modern approach to teaching mathematical methods for physical sciences using Mathematica in this insightful conference talk. Discover how UC Irvine implements a paperless curriculum utilizing an ebook text composed of Mathematica notebooks. Learn about the innovative assignment submission process where students complete and submit their work entirely through notebooks. Gain insights into the experimental web interface for the undergraduate version, which employs Wolfram cloud APIs to automatically grade complex symbolic input. Delve into the course structure, including its introduction, overview, table of contents, required books, criteria, and the unique features of the ebook. Examine practical examples and understand how this system enhances the learning experience for both undergraduate and graduate students in physical sciences.