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Learn about the three FDA-approved medications for treating opioid use disorder in this 17-minute educational video from Yale University's addiction treatment course. Discover how methadone, buprenorphine, and naltrexone work at the molecular level by interacting with mu opioid receptors, and understand their distinct mechanisms as full agonist, partial agonist, and antagonist respectively. Explore the clinical benefits, potential risks, and specific administration requirements for each medication, while gaining insights into important treatment considerations including proper dosing protocols, potential side effects, and optimal therapy duration. Master the role of naloxone (Narcan) in overdose prevention and risk reduction strategies. Designed for healthcare providers, this lesson uses clear analogies and evidence-based research to demystify the pharmacological science behind medication-assisted treatment, offering practical clinical guidance for prescribing these life-changing interventions that help patients reduce cravings, avoid withdrawal symptoms, and successfully rebuild their lives in recovery.
