Genetic Engineering - From DNA Structure to Protein Synthesis

Explore the fundamentals of genetic engineering in this 47-minute lecture from Yale University's Frontiers of Biomedical Engineering course. Delve into the molecular structure of DNA, including backbone, base composition, base pairing, and nucleic acid directionality. Learn about DNA synthesis, transcription, RNA splicing, translation, and post-translational processing required to produce proteins like insulin from genetic code. Understand the genetic code and discover RNA interference as a method to control gene expression and its potential applications in disease treatment. The lecture covers six chapters: Introduction, Building Blocks of DNA, Structure of DNA and RNA, Central Dogma and DNA Synthesis, Genetic Code and Protein Synthesis, and Control of Gene Expression. Access complete course materials on the Open Yale Courses website for this Spring 2008 recording.