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Zhengzhou University

Medical Molecular Genetics

Zhengzhou University via XuetangX

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Overview

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Medical molecular genetics focuses on the relationship between disease and heredity. It studies the structure, function and mutation effect of genes at the molecular level, and explores the occurrence and development of genetic diseases, providing theoretical basis and technical means for the diagnosis, treatment and prevention of genetic diseases.




Syllabus

  • Chapter 1 Basic Theory of Medical Genetics
    • 1.1 The characteristics and forms of genetic mutations
    • 1.2 Monogenic inheritance
    • 1.3 Unclassical Mendelian inheritance
    • 1.4 Multi-genetic legacy
    • 1.5 Human chromosomes and chromosomal aberrations
    • 1.6 Chromosomal disorder
  • chapter 2 mitochondrial genetics and mitochondrial disease
    • 2.1 Overview of mitochondria
    • 2.2 Inheritance of mitochondrial genes
    • 2.3 Mutations in mitochondrial genes and characteristics of mitochondrial disease
    • 2.4 Mitochondrial diseases
    • 2.5 Mitophagy
  • Chapter 3 Tumor Genetics
    • 3.1 Genetic basis of tumorigenesis
    • 3.2 Genomic instability and tumorigenesis
    • 3.3 Oncogene
    • 3.4 Tumor suppressor gene
    • 3.5 Genetic theory of tumorigenesis
    • 3.6 Molecular diagnosis and targeted therapy of tumor
  • chapter 4 Epigenetics
    • 4.1 Concept and Characteristics of Epigenetics
    • 4.2 Epigenetic modification mechanism
    • 4.3 The Formation and Regulatory Mechanism of microRNA
    • 4.4 The Formation and Regulatory Mechanism of LncRNA
    • 4.5 Epigenetics and Diseases
  • chapter 5 sequencing Technology and Visualization
    • 5.1 Overview of sequencing Technology
    • 5.2 First Generation Sequencing and Application
    • 5.3 Next Generation Sequencing and Application
    • 5.4 Third Generation Sequencing and Application
  • Chatper 6 Introduction to proteomics technology and its application
    • 6.1 Introduction to proteomics technology and its application
    • 6.2 Proteomic data acquisition and analysis
    • 6.3 Gene annotation and functional classification
    • 6.4 Gene function prediction
    • 6.5 Abnormal protein structure and diseases
  • Chapter 7 Gene Editing Technology and Applications
    • 7.1 the evolution of gene editing
    • 7.2 ZFNs and TALENs
    • 7.3 CRISPR/Cas9 technology
    • 7.4 applications of CRISPR/Cas9 technology
  • Chapter 8 Clinical Genetics
    • 8.1 Diagnosis of genetic disease
    • 8.2 Prenatal diagnosis
    • 8.3 Genetic disease treatment
    • 8.4 genetic counseling
    • 8.5 Estimation of risk of recurrence of genetic disease
  • Final Exam

    Taught by

    Hong Zheng, Ying He, Hui Chen, Qingchuan Feng, Jia Jing, Jia Liyun, Xu Yan, and Shang Guohui

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