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Zhengzhou University

Medical Immunology

Zhengzhou University via XuetangX

Overview

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Medical Immunology is a pivotal bridge between basic and clinical medicine. It explores how the human immune system is structured, how it functions and how it is regulated, and examines its critical role in the onset and development of diseases. As a frontier of life sciences, immunology has a remarkable past and is evolving faster than ever today. It deeply integrates with molecular biology, preventive medicine, bioinformatics and other fields, unlocking fundamental truths about life and delivering groundbreaking innovations in immunological testing, prevention and treatment.

Many of the most pressing medical problems of our time are being solved through advances in immunology. Designed as an advanced foundational course for graduate students, this MOOC dives deep into the mechanisms and latest breakthroughs in immune-related diseases, alongside state-of-the-art techniques in immunological diagnostics, prophylaxis and therapy. Our goal is to expand your academic horizons, ignite your curiosity and creativity, and inspire you to push the boundaries of medical research and grow into outstanding researchers.

 



Syllabus

  • Chapter 1 Introduction
    • 1.1 Introduction to Medical Immunology
  • Chapter 2 B Cells and Humoral Immune Response
    • 2.1 B Cell Differentiation and Development
    • 2.2 B cells Central Tolerance Induction
    • 2.3 Surface Molecules of B Cells and Their Functions
    • 2.4 Recognition and Activation of B Cells in Response to TD Antigens
    • 2.5Proliferation, Differentiation and Effector Phases of B Cells Stimulated by TD‑A
    • 2.6 Immune Response of B Cells to TI Antigens
  • Chapter 3 Antibodies
    • 3.1 Structure of Antibodies
    • 3.2 Functions of Antibodies
    • 3.3 Artificial Preparation of Antibodies
    • 3.4 Applications of Monoclonal Antibodies
  • Chapter 4 T Cells and Cellular Immune Response
    • 4.1 Development and Differentiation of T Cells in the Thymus
    • 4.2 T Cell Surface Molecules and Their Functions
    • 4.3 Antigen Recognition by T Cells
    • 4.4 T Cell Activation, Proliferation and Differentiation
    • 4.5Immune Effector Functions of Th1, Th2, Tfh and Th17 Cells
    • 4.6 Immune Effector Functions of CTLs
    • 4.7 Immune Effector Functions of Treg Cells
    • 4.8 Processing and Presentation of Endogenous Antigens
    • 4.9 Processing and Presentation of Exogenous Antigens
  • Chapter 5 Innate Immunity
    • 5.1 Overview of Innate Immune Responses
    • 5.2 Cells Involved in Innate Immune Responses - Monocytes/Macrophages
    • 5.3 Cells Involved in Innate Immune Responses - NK (Natural Killer) Cells
    • 5.4 Cells Involved in Innate Immune Responses - γδT Cells
    • 5.5 Phases, Characteristics of Innate Immune Response, and its Relationship with Adaptive Immune Responses
    • 5.6 Cytokines
  • Chapter 6: Immune Tolerance
    • 6.1 Overview of Immune Tolerance
    • 6.2 Types and Influencing Factors of Immune Tolerance
    • 6.3 Mechanisms of Immune Tolerance
    • 6.4 Artificial Intervention of Immune Tolerance
  • Chapter 7: Infection Immunity
    • 7.1 Immunity Against Extracellular Bacteria
    • 7.2 Immunity Against Intracellular Bacteria
    • 7.3 Immunity Against Viruses
  • Chapter 8: Hypersensitivity Reactions
    • 8.1 Pathogenesis of Type I Hypersensitivity
    • 8.2 Common Type I Hypersensitivity Diseases and Their Treatment
    • 8.3 Type II Hypersensitivity
    • 8.4 Type III Hypersensitivity
    • 8.5 Type IV Hypersensitivity
  • Chapter 9: Immunodeficiency Diseases and Autoimmune Diseases
    • 9.1 Primary Immunodeficiency Diseases
    • 9.2 Diagnosis and Treatment of Primary Immunodeficiency Diseases
    • 9.3 Acquired Immunodeficiency Diseases
    • 9.4 Factors Associated with the Development of Autoimmune Diseases
    • 9.5 Common Autoimmune Diseases and Their Immunopathological Mechanisms
    • 9.6 Treatment of Autoimmune Diseases
    • 9.7 Application and Prospects of Treg Cells in the Treatment of Autoimmune Diseases
  • Chapter 10: Tumor Immunity
    • 10.1 Tumor Antigens
    • 10.2 Anti-Tumor Immune Mechanisms
    • 10.3 Mechanisms of tumor immune escape
    • 10.4 Overview of Tumor Immunotherapy
    • 10.5 Tumor Immunotherapy —Immune Checkpoint Blockade Therapy
    • 10.6 Tumor Immunotherapy — Regulatory T Cells (Treg)
    • 10.7 Tumor Immunotherapy — CAR-T Cell Therapy
  • Chapter 11: Transplantation Immunity
    • 11.1 Immune Mechanisms of Transplant Rejection Reactions
    • 11.2 Clinical Types of Transplant Rejection
    • 11.3 3.Principles of Prevention and Treatment of Transplant Rejection
  • Chapter 12: Immunological Detection and Prevention
    • 12.1 Detection of Antigens or Antibodies
    • 12.2Detection of Immune Cell Functions
    • 12.3 Immunoprophylaxis
    • 12.4 Immunotherapy
  • Examination

    Taught by

    Xiaoyan Xuan, Min Li, Xuan Yang, Wenqiao Zang, Qianru Li, and Pingping Liu

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