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Southeast University

分子生物学

Southeast University via XuetangX

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Overview

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This course introduces molecular biology from macromolecular structure through DNA replication, transcription, RNA processing, translation, and post-translation events. It also covers genomic sequencing, functional genomics, and proteomics.

Syllabus

  • Unit 1 Fundations of Molecular Biology
    • 1.1 History of molecular biology
    • 1.2 Structure of macromolecules
  • Unit 2 DNA Replication I
    • 2.1 General features of DNA replication
    • 2.2 Enzymology of DNA Replication
    • 2.3 DNA damage and Repair
  • Unit 3 DNA Replication II
    • 3.1 Detail mechanisms of DNA replication I
    • 3.2 Detail mechanisms of DNA replication II
    • 3.3 Detail mechanisms of DNA replication III
    • 3.4 Detail mechanisms of DNA replication IV
  • Unit 4 DNA recombination
    • 4.1 DNA recombination
    • 4.2 Site-specific recombination
  • Unit 5 Transcription in Prokaryotes
    • 5.1 Introduction
    • 5.2 Transcription in prokaryotes
    • 5.3 Transcription regulation in prokaryotes
  • Unit 6 Transcription in Eukaryotes I
    • 6.1 Eukaryotic RNA Polymerases and Their Promoters
    • 6.2 General Transcription Factors in Eukaryotes
  • Unit 7 Transcription in Eukaryotes II
    • 7.1 Transcription Activators in Eukaryotes
    • 7.2 Chromatin Structure and Its Effects on Transcription
  • Unit 8 RNA Processing Events I
    • 8.1 Introduction of coding RNAs
    • 8.2 Splicesome
    • 8.3 Splicing Specificity
    • 8.4 Autosplicing
  • Unit 9 RNA Processing Events II
    • 9.1 Capping
    • 9.2 Polyadenylation
    • 9.3 Coordination
    • 9.4 Methylation
    • 9.5 Termination
  • Unit 10 RNA Processing Events III
    • 10.1 Introduction of noncoding RNAs
    • 10.2 trans-splicing, RNA editing and guide RNA
    • 10.3 5'- and 3'-UTRs
    • 10.4 siRNAs and miRNAs
  • Unit 11 RNA Processing Events IV
    • 11.1 lncRNAs
    • 11.2 circRNAs
    • 11.3 CRISPR RNAs
    • 11.4 piRNAs
  • Unit 12 Translation I
    • 12.1 Overview of translation
    • 12.2 The genetic code
    • 12.3 Ribosome
  • Unit 13 Translation II
    • 13.1 Translation initiation
    • 13.2 Translation elongation
  • Unit 14 Tranlation III
    • 14.1 Translation termination
    • 14.2 Posttranslation events
  • Unit 15 Omics
    • 15.1 Genomic sequencing
    • 15.2 Functional genomics
    • 15.3 Proteomics
  • Final Exam

    Taught by

    Zi Chao Zhang, Henry H. Xie, and Moyi Li

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